Pro Picks: Defending Super Bowl champion Seahawks will hand Kanas City its first loss

Kenneth Walker III is going back to Seattle with undefeated Kansas City to face the team he helped lead to the Super Bowl last season.

Walker, Patrick Mahomes and Co. visit the Seahawks (3-3) on Sunday night.

Walker leads the NFL in rushing with 665 yards despite already taking a bye week while Seattle has missed the Super Bowl MVP. The Seahawks are 18th in rushing and have averaged 3.9 yards per attempt.

Sam Darnold has seven interceptions in slightly more than four games and the Seahawks haven’t made up for Walker’s absence. But they have Jaxon Smith-Njigba, who leads the NFL with 717 receiving yards and seven touchdowns.

Walker has provided Kansas City with a balanced attack. The team hasn’t had a 1,000-yard rusher since Mahomes became the starter in 2018. Walker is on pace for 2,261 yards, which would set a single-season record.

Despite their struggles, the Seahawks are 2 1/2-point favourites. Pro Picks likes the home team.

Seahawks: 23-20

New England (4-2) at Chicago (4-2)

Line: Bears minus 3

Drake Maye has led the banged-up Patriots to three straight wins. A.J. Brown returned last week but dropped three passes. Caleb Williams was nearly flawless in his first game back, leading the Bears to 31 points. Chicago plays consecutive primetime games against last season’s Super Bowl opponents, starting with the Thursday night matchup.

Bears: 24-20

Pittsburgh (4-2) vs. New Orleans (2-4), in Paris

Line: Steelers minus 3

Aaron Rodgers led the Steelers back from a 13-point deficit in Tampa Bay, relying on DK Metcalf and rookie Germie Bernard. The Saints got their run game going in a win over the Giants. Both teams are spending the week in Paris before playing the NFL’s first regular-season game there. The Steelers have covered the spread four of the past five games.

Steelers: 23-18

Cincinnati (3-2) at Baltimore (4-2)

Line: Ravens minus 2 1/2

Joe Burrow and the Bengals are coming off a bye. Their defence had a great start but has struggled against the run in the past three games. The Ravens still might not have Lamar Jackson so Tyler Huntley would start his third straight game. Baltimore is eighth in rushing and relying on Derrick Henry is a smart move if Jackson is out.

Bengals: 22-17

Cleveland (4-2) at Tennessee (1-5)

Line: Browns minus 1 1/2

Deshaun Watson led another fourth-quarter game-winning drive for the Browns, but the offence has struggled despite the team’s winning record. Tennessee’s offence is last in the NFL. The Titans beat the Colts for their first win, but Cam Ward had another rough outing.

Upset special: Titans, 20-17

Indianapolis (2-4) at Minnesota (5-0)

Line: Vikings minus 6 1/2

The Colts’ struggles cost general manager Chris Ballard his job. Coach Shane Steichen is clearly on the hottest of seats and the team has to find ways to win. The undefeated Vikings are coming off a bye. They’ve been winning on defence and special teams and need Kyler Murray to get the offence going.

Vikings: 23-18

Miami (0-5) at New York Jets (2-4)

Line: Jets minus 4 1/2

The Jets haven’t won an AFC East game under coach Aaron Glenn, going 0-7. They have their best chance this week against Miami. The winless Dolphins are coming off a bye. QB Malik Willis has the worst passer rating (68.4) among starters.

Jets: 20-17

New York Giants (3-2-1) at Houston (2-4)

Line: Texans minus 10 1/2

J.J. McCarthy is replacing Jameis Winston, who had a winning record after taking over for Jaxson Dart. McCarthy will face an underachieving defence stacked with talent. C.J. Stroud is playing great football for the Texans, who’ve won two in a row.

Texans: 26-17

San Francisco (6-0) at Atlanta (2-4)

Line: 49ers minus 3 1/2

Christian McCaffrey vs. Bijan Robinson in a matchup of all-pro backs who are close friends and train together. The undefeated 49ers keep winning despite losing key players because they have Brock Purdy. The Falcons lost two games to start the season, won two in a row and have now lost two straight. Atlanta is 3-2 ATS in past five games against San Francisco.

49ers: 22-20

Tampa Bay (1-5) at Carolina (3-2)

Line: Panthers minus 3 1/2

Baker Mayfield is aiming to return for the Buccaneers, who have lost 12 of their past 15 games. The Bucs have played tough defence but their offence is among the bottom third. Bryce Young is playing his best football for the Panthers. He has 11 TDs and only two picks.

Panthers: 23-20

Denver (4-2) at Arizona (2-4)

Line: Broncos minus 4 1/2

Bo Nix is taking plenty of heat despite Denver’s winning record. Nix and the offence have to get on track. The Broncos have faced a tough schedule that doesn’t get easier after Arizona. The Cardinals beat the Rams on the road last week and have to carry that momentum into a difficult matchup.

Broncos: 24-16

Green Bay (4-2) at Detroit (3-2)

Line: Lions minus 3

The Packers have won three in a row, the defence has been out and Josh Jacobs is coming back to boost the offence with Micah Parsons working toward his return. The Lions have the league’s worst defence that’s sometimes offset by a prolific offence. This one should be a shootout.

Lions: 30-26

Los Angeles Rams (2-4) at Las Vegas (3-3)

Line: Rams minus 4 1/2

The Rams haven’t played close to Super Bowl favourites. And, injuries are piling up with Davante Adams now going down for several weeks. But they still have Sean McVay, Matthew Stafford, Puka Nacua and Aaron Donald. The Raiders have lost three in a row but Kirk Cousins is playing well so hold off on Fernando Mendoza. A defence that’s allowed 30-plus points three straight games has been the problem.

Best bet: Rams, 31-20

Dallas (2-4) at Philadelphia (2-4)

Line: Cowboys minus 4 1/2

The Cowboys have an opportunity in a wide-open NFC East, but have had issues on defence and now a dynamic offence has sputtered. The Eagles are reeling and won’t have Jalen Hurts likely for the rest of the season. Tanner McKee makes his second straight start for Philadelphia.

Cowboys: 24-23

Last week: Straight up: 8-6. Against spread: 7-7.

Overall: Straight up: 55-37-1. Against spread: 45-45-2.

Best bet: Straight up: 3-3. Against spread: 2-4.

Upset special: Straight up: 2-4. Against spread: 2-4.